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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MEF2D All Species: 18.79
Human Site: S345 Identified Species: 34.44
UniProt: Q14814 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14814 NP_005911.1 521 55938 S345 Q L T S A E L S S L P A F S S
Chimpanzee Pan troglodytes XP_001165500 521 55889 S345 Q L T S A E L S S L P A F S S
Rhesus Macaque Macaca mulatta XP_001103222 500 53974 S343 S L T S A D L S A L Q G F N S
Dog Lupus familis XP_547534 525 56508 L345 A S Q S T H S L T T P V V S V
Cat Felis silvestris
Mouse Mus musculus Q63943 514 54974 S345 Q L P S A E L S S L P A F S S
Rat Rattus norvegicus O89038 507 54350 S345 S S L P A F S S P A G L A L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507540 505 54598 L345 Y S L T S A D L S A L Q G F N
Chicken Gallus gallus Q9W6U8 499 53650 S347 S L T S A D L S A F E G F N S
Frog Xenopus laevis Q03413 498 54053 L345 Y Q L T S A D L A S L S T F S
Zebra Danio Brachydanio rerio NP_571392 529 57466 P345 T A L Q A F T P S G A L L P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40791 539 57097 S345 S T P P P A T S P V S I K V K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38847 268 30310 A127 L E Q Q L Y H A L I T V R E R
Baker's Yeast Sacchar. cerevisiae Q12224 676 73465 S345 A I P S E P S S A S S T S A N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 53.7 72.5 N.A. 96.1 94.4 N.A. 54.1 54.7 73.6 70.1 N.A. 28 N.A. N.A. N.A.
Protein Similarity: 100 99.8 63.9 75.8 N.A. 97.1 95.5 N.A. 64.8 64.3 82.5 78.2 N.A. 39.5 N.A. N.A. N.A.
P-Site Identity: 100 100 60 20 N.A. 93.3 13.3 N.A. 6.6 53.3 6.6 13.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 80 26.6 N.A. 93.3 13.3 N.A. 26.6 73.3 33.3 13.3 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 22.2 22.1 N.A.
Protein Similarity: N.A. N.A. N.A. 34.9 38.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 54 24 0 8 31 16 8 24 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 16 16 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 0 8 24 0 0 0 0 8 0 0 8 0 % E
% Phe: 0 0 0 0 0 16 0 0 0 8 0 0 39 16 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 8 8 16 8 0 16 % G
% His: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 8 0 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % K
% Leu: 8 39 31 0 8 0 39 24 8 31 16 16 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 16 16 % N
% Pro: 0 0 24 16 8 8 0 8 16 0 31 0 0 8 0 % P
% Gln: 24 8 16 16 0 0 0 0 0 0 8 8 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % R
% Ser: 31 24 0 54 16 0 24 62 39 16 16 8 8 31 47 % S
% Thr: 8 8 31 16 8 0 16 0 8 8 8 8 8 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 8 0 16 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _